BRAIN 双语文章
BRAIN bilingual article
白藜芦醇通过激活 Sirt1/Gpx4 通路减轻大鼠局灶性脑缺血损伤
Resveratrol Treatment Attenuates Focal Cerebral Ischaemic Injury in Rats by Activating the Sirt1/Gpx4 Pathway to Inhibit Ferroptosis
2026年3月19日，BRAIN 发表了一项由中国研究人员完成的神经科学研究，探讨白藜芦醇对大鼠局灶性脑缺血损伤的神经保护作用。
作者：Xinli Qu、Hui Xiong、Shaoshuai Fang、Pingfan Zeng、Liuyang Deng 和 Peng Wang。
研究采用光化学栓塞法建立大鼠局灶性脑缺血模型，并通过神经功能评分、粘附物去除实验、TTC染色以及对GSH、铁离子、ROS和MDA等指标的检测，评估脑损伤与铁死亡相关变化。
结果显示，白藜芦醇治疗可改善神经功能缺损，缩短粘附物去除时间，减少脑梗死面积和脑含水量，并减轻脑缺血引起的神经损伤。同时，它可恢复GSH和铁离子水平，降低ROS和MDA水平，并促进Sirt1和Gpx4蛋白的表达。
研究表明，白藜芦醇可能通过上调Sirt1和Gpx4蛋白表达、抑制铁死亡，从而减轻脑缺血损伤并发挥神经保护作用。
On March 19, 2026, BRAIN published a neuroscience study by Chinese researchers investigating the neuroprotective effects of resveratrol in a rat model of focal cerebral ischaemia.
Authors: Xinli Qu, Hui Xiong, Shaoshuai Fang, Pingfan Zeng, Liuyang Deng and Peng Wang.
The researchers used photochemical embolisation to produce focal cerebral ischaemic injury in rats. Neurological scoring, the adhesive removal test, TTC staining and measurements of GSH, iron ions, ROS and MDA were used to assess brain injury and ferroptosis-related changes.
Resveratrol treatment improved neurological deficits, shortened adhesive removal time, reduced cerebral infarction area and brain water content, and alleviated neurological damage. It also restored GSH and iron ion levels, reduced ROS and MDA levels, and promoted the expression of Sirt1 and Gpx4 proteins.
The study suggests that resveratrol may protect against cerebral ischaemic injury by increasing Sirt1 and Gpx4 protein expression and inhibiting ferroptosis.