It is a genuine pleasure and a great honor to announce the upcoming publication, in just a few days, of Issue 4 of Volume 16 (December 2025) of BRAIN. Broad Research in Artificial Intelligence and Neuroscience. This issue is, without exaggeration, one of the most diverse and complex volumes published so far—both through its thematic richness and through the extraordinary geographical diversity of its authors and contributing institutions.

A Strategic Objective Achieved: 4 Continents United Through Research

In this issue, we include works originating from Europe, Asia, Africa, and North America. The authors represent academic institutions and research centers from Romania, Italy, Spain, Czech Republic, Bulgaria, Turkey, Saudi Arabia, Pakistan, Algeria, Finland, the United Arab Emirates, Ukraine, Hungary, Slovakia, Israel, Switzerland, and the United States.
Although Romanian authors are numerous, the international contributions are remarkable, ensuring the truly global character that BRAIN aims to promote as a major objective.

We particularly highlight the presence of:
👉 Professor Edward Watkins Jr. Clifton (University of North Texas, USA) — author of Article 33, a prestigious contribution on the evolution of research in emotional abuse and suicide;
👉 Italian professors Vincenzo Mastronardi and Monica Calderaro — authors of Article 39, an exceptional work at the intersection of psychology, ethology, criminology, and the dynamics of human emotions.

Thus, Issue 4 becomes not only an issue of diversity, but also one of international excellence in AI, neuroscience, and behavioral sciences.

The Four Major Themes of This Issue

The structure of the journal, organized into four major categories, reflects the breadth and emerging directions of contemporary research.

A. Artificial Intelligence, Society & Digital Innovation

This section explores how AI technologies interact with society, education, digital culture, and emerging social environments.
Notable contributions include:
👉 studies from the Czech Republic on AI support for vulnerable children;
👉 research from Bulgaria on emotional and social competencies of AI systems;
👉 analyses of Romanian students’ attitudes toward AI;
👉 intelligent automation of educational processes;
👉 a Russia–UAE transnational work on metasystemic transitions in education;
👉 applied research in medical tourism (Turkey), sentiment analysis and AI robustness (Saudi Arabia), and hate speech detection (Pakistan);
👉 Romanian studies on route optimization, computational vision for Asian traffic systems, and comparative analysis of biometric verification systems (Algeria–Finland).

Section A is one of the most geographically diverse, demonstrating that AI is a truly global phenomenon, with applications ranging from education to security, mobility, and digital media.

B. Neurosciences in the Age of AI

This category brings together neurobiological, cognitive, educational, and psychophysiological perspectives, emphasizing how AI can support neuroscience.
Key contributions include:
👉 a comprehensive Ukrainian study on the use of AI technologies in training master’s students in education, integrating neuroscience with modern pedagogy;
👉 an India–USA study on EEG data and consumer decision-making in digital environments;
👉 neuropsychological analyses applied to sports, sustainability, and physical performance;
👉 a refined Spanish theoretical work on neuroentropy and consciousness;
👉 a Romanian experimental study on fear conditioning and prefrontal EEG correlates.

Section B is perhaps the most conceptual, offering both original empirical research and theoretical syntheses of neural and neurocognitive models assisted by AI.

C. Biomedical & Clinical AI Applications

Category C brings together clinical medicine, pathology, oncology, gynecology, neuropsychiatry, immunology, eating behavior research, and AI-based biomedical predictive models.
Major contributions include:
👉 an extensive study on T. gondii, neuroinflammation, and psychosis, along with AI’s role in parasitic psychiatry;
👉 an article by Utku Köse, Associate Editor, on personalized models for pediatric chemotherapy response;
👉 research integrating psychoneuroimmunology into cervical neoplasia risk stratification;
👉 a complex work on gestational diabetes prediction using multimodal AI models;
👉 ENT and maxillofacial oncology analyses integrating histopathology, imaging, and AI;
👉 an original contribution on the comorbidity between schizophrenia and oral health, integrating oxidative stress and nutrition;
👉 a clinical study on gliosarcoma, with focus on imaging, pathology, and clinical correlations.

Category C is marked by medical rigor, interdisciplinarity, and an applied orientation—AI becomes a critical tool in prediction, diagnosis, and advanced clinical analysis.

D. Psychology, Psychotherapy, Clinical Neuroscience & Mental Health

This rich section integrates clinical psychology, psychotherapy, ethology, psychiatry, educational psychology, psychometrics, and conceptual research.
Key contributions include:
👉 a Slovak study on self-harming behaviors and the psychobiological model of temperament;
👉 an article by Professor Shlomo Mendlovic (Israel), Associate Editor, on responsible integration of AI in psychotherapy;
👉 a preliminary model linking nutrition and neuropsychiatric symptoms (Romania–Hungary);
👉 a biosemiotic synthesis on aesthetics and its psychological implications;
👉 a Swiss study on empathy and limitations of AI chatbots;
👉 research on emotional intelligence and academic performance;
👉 validation of a Romanian spiritual intelligence scale;
👉 modular psychotherapy for severe depression with suicide risk;
👉 Article 33 — a landmark American contribution summarizing 40 years of research on emotional abuse and suicide;
👉 computational models on lithiasis and diet;
👉 histopathological and computational analyses of bladder tumors;
👉 Article 39 — an international collaboration (Italy–Romania) on physiological and behavioral responses of animals to human emotions.

Section D reinforces one of the journal’s core objectives: integrating cognitive, affective, clinical, and social sciences.

Acknowledgments to the Editorial Team

This issue would not have been possible without the vast effort and dedication of an international team.

Editorial team:
👉 Shlomo Mendlovic – Associate Editor (author in this issue)
👉 Utku Köse – Associate Editor (author in this issue)
👉 Jude Hemanth – Associate Editor

Essential role in editorial coordination:
👉 Adriana Climescu-Haulică, Director at Avantiv Limited,
researcher at École Polytechnique Fédérale de Lausanne, Cambridge, UK — for her substantial contribution to evaluation and international coordination.

Editorial coordination & production:
👉 Sara Rihaneova – Managing Editor (Bratislava)
👉 Claudia Tugulea – Production Editor
👉 Andreea Ababei, Diana Ciubotaru, Andrada Mucea – Scientific Editors
👉 Daria Dudau, Ana Boboc, Luiza Antuca – Editorial Assistants
👉 Florin Alexandru Bude – Technical Team Coordinator

We also thank our distinguished reviewers from the United Kingdom, France, Italy, Czech Republic, Slovakia, and Romania, who helped maintain the high academic standards of the journal.

In Conclusion

Issue 4 of Volume 16 of BRAIN is a celebration of interdisciplinarity, international openness, and the fruitful dialogue between artificial intelligence, neuroscience, psychology, and clinical sciences.
It is a volume in which four continents and dozens of institutions converge around a shared mission:
👉 understanding the mind, brain, and society through
👉 emerging technologies and rigorous scientific knowledge.

We thank all our authors, editors, reviewers, and readers!

In the spirit of ongoing modernization and broader accessibility, we warmly invite the readers, authors, and reviewers of BRAIN to install the official mobile app, available at:
👉 https://brain-app-two.vercel.app/

Through the app, you can easily follow editorial news, citation alerts, calls for papers, and the international scientific activity connected to our journal.

With respect and enthusiasm,
The Editorial Team of BRAIN. Broad Research in Artificial Intelligence and Neuroscience